VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Antioxidant activity of natural and synthetic quinones

   
Storozhok N.M., Drulle A.Ya., Login I.Ya., Dregeris I.Ya., Khrapova N.G., Burlakova E.B.
PubMed Id: 7771081
Year: 1995  Volume: 41  Issue: 1  Pages: 16-21
Antioxidation activity (AOA) of ubiquinone (Q10), phylloquinone (vitamin K1), menadione as well as of the newly synthesized analogues of vitamin K1--N-derivatives of 2-methyl-3-aminomethyl 1.4-naphthoquinone, producing autocomplexes with intramolecular transfer of electrons, was studied in the model system of the methyl oleate initiated oxidation. The menadione AOA was shown to be 2-fold higher as compared with the inhibitory activity of natural quinones. Activity of AK-40 and AK-49, artificial analogues of vitamin K1, was higher 2.6-fold than that of ubiquinone and phylloquinone and 1.4-fold higher than menadione activity. At the same time, AOA of ubiquinone and phylloquinone was 1.5-fold lower than the tocopherol activity, while naphthoquinones AK-40 and AK-49 were 2-fold more active as compared with tocopherol but their activity was 2-fold lower than ionol. Mechanism of natural and synthetic quinones action as well as properties of their long chain analogues are discussed
Download PDF:  
Citation:

Storozhok, N. M., Drulle, A. Ya., Login, I. Ya., Dregeris, I. Ya., Khrapova, N. G., Burlakova, E. B. (1995). Antioxidant activity of natural and synthetic quinones. Voprosy Meditsinskoi Khimii, 41(1), 16-21.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
◄        ►