VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effectiveness of lignin as a protective factor in exposure to polychlorinated biphenyls

   
Tutel'ian V.A., Lashneva N.V., Gadzhieva Z.M., Vorobeĭchik T.A., Shatrov G.N., Smirnov V.G.
PubMed Id: 7793091
Year: 1995  Volume: 41  Issue: 2  Pages: 25-29
The effect of lignin on some biochemical and morphological parameters was studied in rats after short-term treatment with the industrial mixture of polychlorinated biphenyls (PCB) sovol at a daily dose of 5 mg/kg, 5 times a week for a fortnight. Dietary supplementation of 5% lignin as the drug polyphenane did not protect the induction of the rat hepatic P-450 cytochrome monooxygenase system, which is typical of the action of PCB, but slightly modified the inducing effect of sovol. In the polyphepane-fed animals, there was a decrease in impairments of the liver structure and its more rapid normalization than in control rats. The lower hepatotoxic effect of the PCB mixture when lignin was added to the ration was likely to be associated with the action of lignin as a nonspecific polyvalent enterosorbent. It is concluded that polyphepane is a promising protective agent on exposure to PCB
Download PDF:
Reference:

Tutel'ian V.A., Lashneva N.V., Gadzhieva Z.M., Vorobeĭchik T.A., Shatrov G.N., Smirnov V.G. (1995) Voprosy meditsinskoi khimii, 41(2), 25-29.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
        

© Institute of Biomedical Chemistry, Moscow, Russia