A procedure was developed to purify ferritin from the human brain tissue. The preparation is a heavy chain of ferritin. The level of ferritin in biological fluids was evaluated using the sandwich solid-phase immunoassay. This fraction of ferritin was found in the cerebrospinal fluid of patients with brain tumors. Content of the ferritin heavy chain in cerebrospinal fluid correlated with the rate of brain tissue malignancy.
Morozov S.G. et al. Immunoenzyme analysis of ferritin in diagnosing brain tumors // Voprosy meditsinskoi khimii. - 1995. - V. 41. -N 2. - P. 43-45.
Morozov S.G. et al., "Immunoenzyme analysis of ferritin in diagnosing brain tumors." Voprosy meditsinskoi khimii 41.2 (1995): 43-45.
Morozov, S. G., Chekhonin, V. P., Belopasov, V. V., Panchenko, L. F., Kachkov, I. A., Biktimirov, R. G., Abramova, O. S. (1995). Immunoenzyme analysis of ferritin in diagnosing brain tumors. Voprosy meditsinskoi khimii, 41(2), 43-45.