VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Reverse absorption of serotonin by synaptosomes and its level in the rat cerebral cortex in acute and chronic stress

   
Skurygin V.P.
PubMed Id: 8585178
Year: 1995  Volume: 41  Issue: 3  Pages: 39-41
Acute stress was simulated in Wistar rats by means of uncontrolled electric shock within 6 hrs; chronic stress, after the first 6-hr course, was developed within 9 days using 1-h daily treatment. Within 18 hrs of the acute stress occurring concentration of serotonin was decreased 2-fold in tissues of brain cortex, while reverse absorption of the neurotransmitter in synaptosomes was increased 3-fold. Under conditions of chronic stress concentration of serotonin tend to increase, whereas reverse absorption by nerve endings was decreased, which appear to occur due to brain adaptation to chronic stress.
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Reference:

Skurygin V.P. (1995) Voprosy meditsinskoi khimii, 41(3), 39-41.
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