VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Changes in the proteolytic activity of venous blood leukocyte nuclei from gamma-irradiated rabbits

   
Surkenova G.N., Malakhova L.V., Gaziev A.I.
Section: Experimental Study
PubMed Id: 8571576
Year: 1995  Volume: 41  Issue: 4  Pages: 12-14
In terms of their capacity to decompose a casein substrate, the activity of nuclear proteinases was studied in the leukocytes of the rabbit blood taken before and after their joint gamma-irradiation. There was a substantial increase in the activity of proteinases in the leukocytic nuclei 2 and 48 hours after animals had been irradiated in a dose of 5 Gy as compared with those obtained prior to irradiation. Ninety six hours after irradiation the activity showed an average decrease to 40-60% of the control level. There was a correlation between the proteolytic activity and the irradiation dose: there were average 1.75- and 3.25-fold activity increases with 2.5 and 5.0 Gy, respectively. The findings provide a rationale for examining the proteinase activity of human peripheral leukocytic nuclei to clinically estimate radiation exposures.
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Surkenova G.N., Malakhova L.V., Gaziev A.I. (1995) Voprosy meditsinskoi khimii, 41(4), 12-14.
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