VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Ability of bone marrow cells to generate active forms of oxygen in C57Bl/6 and BALB/C mice and mutagenic effects of dioxidine

   
Guseva N.V., Durnev A.D., Seredenin S.B.
Section: Experimental Study
PubMed Id: 8571581
Year: 1995  Volume: 41  Issue: 4  Pages: 25-28
Phorbol-myristate acetate- and opsonized zymosan-induced statistically significant differences were shown in the intensity of chemiluminescence occurring in the bone marrow cell suspension. The bone marrow cells from male BALB/c mice showed the most pronounced response to stimulation in the two cases. After 5-day administration of dioxidine (300 mg/kg), the number of the injured metaphases in the bone marrow from the examined animals was 43.6 +/- 2.2 and 23.8 +/- 1.9% in BALB/c and C57B1/6 mice, respectively, which provides evidence for marked strain-specific differences in the cytogenetic effect of this proxidative mutagen. The findings indicated that there was a relationship between the capacity of bone marrow cells of producing APA and the severity of cytogenetic lesions in these cells
Download PDF:  
Citation:

Guseva, N. V., Durnev, A. D., Seredenin, S. B. (1995). Ability of bone marrow cells to generate active forms of oxygen in C57Bl/6 and BALB/C mice and mutagenic effects of dioxidine. Voprosy Meditsinskoi Khimii, 41(4), 25-28.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
◄        ►