VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Inhibition of formation of superoxide radicals in leukocytes of hypercholesteremic patients under the effect of a lipid platelet activation factor antagonist

   
Muzia G.I., Bol'shakova N.S., Cherniad'eva I.F., Kukharchuk V.V., Kulikov V.I.
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PubMed Id: 8571587
Year: 1995  Volume: 41  Issue: 4  Pages: 45-48
A platelet-activating factor (PAF) antagonist was found to inhibit superoxide production in the leukocytes of patients with type IIA hypercholesterolemia. PAF (10(-7)-10(-6) M) alone failed to stimulate superoxide production in intact or PAF-antagonist-treated leukocytes. The PAF-antagonist-induced inhibition of superoxide production was observed in the leukocytes from hypercholesterolemic patients whose plasma cholesterol levels varied from 8.3 to 14.0 mmole/l
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Muzia G.I., Bol'shakova N.S., Cherniad'eva I.F., Kukharchuk V.V., Kulikov V.I. (1995) Voprosy meditsinskoi khimii, 41(4), 45-48.
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