VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Participation of a diazepam-binding inhibitor in the interaction between NAD and GABA-benzodiazepine receptor complex in synaptic membranes

   
Fomenko A.I., Parkhomets P.K., Stepanenko S.P., Donchenko G.V.
PubMed Id: 8619303
Year: 1995  Volume: 41  Issue: 6  Pages: 44-48
Diazepam-binding inhibitor isolated from synaptic membranes exerts a pronounced inhibitory effect on the specific benzodiazepine-receptor binding of 3H-flunitrazepam and simultaneously leads to an increase of synaptosomal uptake of 14C-GAMA. At the same time the inhibitor also depresses the specific binding of 14C-NAD by synaptic membranes, but displaying a greater effect. In both cases the inhibition was competent. Whether the isolated neuropeptide may act as an intermediary in the interaction with the reception system of NAD with GABA-benzodiazepine-receptor complex.
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Fomenko, A. I., Parkhomets, P. K., Stepanenko, S. P., Donchenko, G. V. (1995). Participation of a diazepam-binding inhibitor in the interaction between NAD and GABA-benzodiazepine receptor complex in synaptic membranes. Voprosy Meditsinskoi Khimii, 41(6), 44-48.
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