By mathematically analysing the curves of urinary excretion of vitamins, their plasma and erythrocytic concentrations or of TDP-effect, by constructing and mathematically interpreting the variation curves of distribution of a given plasma concentration of riboflavin and pyridoxal phosphate for 10-14-old-year children suffering from insulin-dependent diabetes mellitus after supplementation of vitamin, as a criterion of normal requirement for vitamin B2, the authors are prone to recommend the concentration of riboflavin over 10 micrograms/ml in plasma and over 96 micrograms/ml in erythrocytes, the hourly excretion of more than 27 micrograms. It has been ascertained that the criteria for the optimal body's requirements for vitamins in diabetes mellitus children do not differ from those in healthy age-matched children. Thus, the value of TDP-effect is less than 1.25, the concentration of pyridoxal phosphate is over 8.4 micrograms/ml plasma, the excretion values of thiamine and 4-pyridoxic acid are 13.5 and 64.0 micrograms/h, respectively
Vrezhesinskaia O.A. et al. Criteria of supply of vitamins B1, B2, and B6 in children with insulin-dependent diabetes mellitus // Voprosy meditsinskoi khimii. - 1995. - V. 41. -N 6. - P. 58-62.
Vrezhesinskaia O.A. et al., "Criteria of supply of vitamins B1, B2, and B6 in children with insulin-dependent diabetes mellitus." Voprosy meditsinskoi khimii 41.6 (1995): 58-62.
Vrezhesinskaia, O. A., Kodentsova, V. M., Kharitonchik, L. A., Trofimenko, L. S., Spirichev, V. B. (1995). Criteria of supply of vitamins B1, B2, and B6 in children with insulin-dependent diabetes mellitus. Voprosy meditsinskoi khimii, 41(6), 58-62.