The inhibitory activities of individual natural antioxdants (AOs), such as alpha-tocopherol (I), beta-carotene (II), vitamin A(III) and their mixtures were comparatively studied when oxidation of microbial polyunsaturated fatty acid esters that predominately contain ethyl arachidonate was initiated; effects of antagonism were found in the combined action of I and II, I and III. The magnitude of antagonism effect was estimated from the difference between the total additive effects of individual AOs and the experimentally determined effects of their mixture. There is a U-dependence of changes in the antagonism values upon II concentrations at steady-state I levels. It was found that in the range of low (10(-8) to 10(-7) M) and high (10(-2) M) concentrations of II, the involvement of antagonism might be relatively low (3.5-4.0%); in the range of 10(-6) to 10(-5) M, there is a concentration 'hole' whose peak (1.25 x 10(-6) M) is as high as 90%. As I levels elevated, antagonism in the mixture decreased. It is suggested that the intermolecular interactions of natural AO during oxidation represent a mechanism for the body's antioxidative homeostasis.
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Storozhok N.M., Kutuzova I.V. (1996) Inhibitory effects of mixtures of alphalpha-tocopherol with b-carotene or vitamin A during oxidation of polyunsaturated fatty acid esters. Voprosy Meditsinskoi Khimii, 42(1), 16-22.
Storozhok N.M. et al. Inhibitory effects of mixtures of alphalpha-tocopherol with b-carotene or vitamin A during oxidation of polyunsaturated fatty acid esters // Voprosy Meditsinskoi Khimii. - 1996. - V. 42. -N 1. - P. 16-22.
Storozhok N.M. et al., "Inhibitory effects of mixtures of alphalpha-tocopherol with b-carotene or vitamin A during oxidation of polyunsaturated fatty acid esters." Voprosy Meditsinskoi Khimii 42.1 (1996): 16-22.
Storozhok, N. M., Kutuzova, I. V. (1996). Inhibitory effects of mixtures of alphalpha-tocopherol with b-carotene or vitamin A during oxidation of polyunsaturated fatty acid esters. Voprosy Meditsinskoi Khimii, 42(1), 16-22.
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