Inhibitory effects of mixtures of alphalpha-tocopherol with b-carotene or vitamin A during oxidation of polyunsaturated fatty acid esters

Storozhok N.M., Kutuzova I.V.
Section: Experimental Study
PubMed Id: 8999653
Year: 1996  Volume: 42  Issue: 1  Pages: 16-22
The inhibitory activities of individual natural antioxdants (AOs), such as alpha-tocopherol (I), beta-carotene (II), vitamin A(III) and their mixtures were comparatively studied when oxidation of microbial polyunsaturated fatty acid esters that predominately contain ethyl arachidonate was initiated; effects of antagonism were found in the combined action of I and II, I and III. The magnitude of antagonism effect was estimated from the difference between the total additive effects of individual AOs and the experimentally determined effects of their mixture. There is a U-dependence of changes in the antagonism values upon II concentrations at steady-state I levels. It was found that in the range of low (10(-8) to 10(-7) M) and high (10(-2) M) concentrations of II, the involvement of antagonism might be relatively low (3.5-4.0%); in the range of 10(-6) to 10(-5) M, there is a concentration 'hole' whose peak (1.25 x 10(-6) M) is as high as 90%. As I levels elevated, antagonism in the mixture decreased. It is suggested that the intermolecular interactions of natural AO during oxidation represent a mechanism for the body's antioxidative homeostasis.
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Storozhok N.M., Kutuzova I.V. (1996) Voprosy meditsinskoi khimii, 42(1), 16-22.
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