Captopril was investigated for its effects on the activity of angiotensin-converting enzyme in the rat blood serum, pituitary, hypothalamus, and striatum, as well as for those on the animals, behavior in the open-field test. During its single administration the agent was found to lower the activity of angiotensin-converting enzyme in all the examined brain regions and serum. During chronic administration captopril decreased the mobility of the animals in the open-field test, diminished, the activity of the enzyme in the hypothalamus and striatum and enhanced it in the pituitary and serum. It is suggested that the effect of captopril might be due to imbalance in the changes of angiotensin-converting enzyme activity in various brain regions of the rats.
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Vernigora A.N., Gengin M.T., Nikishin N.N., Shchetinina N.V. (1996) Effect of captopril on the activity of angiotensin-converting enzyme and on rat behavior in the open field test. Voprosy Meditsinskoi Khimii, 42(1), 34-38.
Vernigora A.N. et al. Effect of captopril on the activity of angiotensin-converting enzyme and on rat behavior in the open field test // Voprosy Meditsinskoi Khimii. - 1996. - V. 42. -N 1. - P. 34-38.
Vernigora A.N. et al., "Effect of captopril on the activity of angiotensin-converting enzyme and on rat behavior in the open field test." Voprosy Meditsinskoi Khimii 42.1 (1996): 34-38.
Vernigora, A. N., Gengin, M. T., Nikishin, N. N., Shchetinina, N. V. (1996). Effect of captopril on the activity of angiotensin-converting enzyme and on rat behavior in the open field test. Voprosy Meditsinskoi Khimii, 42(1), 34-38.
References
Вальдман А.В., Медведев О.С. // Вестн. АМН СССР. - 1982. - N 5. - С. 14-23. Scholar google search
