VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Modulation of complex formation between mieloperoxidase and fibronectin by fibronectin ligands

   
Yankovsky O.Yu., Yablunovskaya I.A., Kokrjakov V.N., Aleshina G.M., Khilatzhetdinova L.R., Govorova N.Yu., Podsukhina G.M., Gavrilova Yu.V., Vakhrushev A.V., Leonova N.V.
PubMed Id: 9148599
Year: 1996  Volume: 42  Issue: 2  Pages: 137-140
Human blood plasma fibronectin immobilised on agarose in physiological interacts with soluble myeloperoxidase (Kd = 2.43 mM). Interaction of myeloperoxidase with fibronectin adsorbed on immobilised gelatin a, natural fibronectin ligand, resulted in formation more stable complex (Kd = 0.94 mM). The presence of thermoaggregated (but not native) IgG in the liquid phase increased a stability of the complex (0.06 mM). It is suggested that myeloperoxidase could represent a component of complex super molecular structure, real immune complex.
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Yankovsky, O. Yu., Yablunovskaya, I. A., Kokrjakov, V. N., Aleshina, G. M., Khilatzhetdinova, L. R., Govorova, N. Yu., Podsukhina, G. M., Gavrilova, Yu. V., Vakhrushev, A. V., Leonova, N. V. (1996). Modulation of complex formation between mieloperoxidase and fibronectin by fibronectin ligands. Voprosy Meditsinskoi Khimii, 42(2), 137-140.
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