VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Autoantibodies to nervous tissue proteins in patients with remote consequences of trauma

   
Morozov S.G., Asanova L.M., Gnedenko B.B., Panchenko L.F., Lavrova T.N.
PubMed Id: 9148602
Year: 1996  Volume: 42  Issue: 2  Pages: 147-152
20 samples of serum of patients with remote consequences of brain trauma were tested to detect autoantibodies (a-AB) against brain proteins S-100 and NKP. Essential pathology was not found out by standard solid-phase immunoassay. The original method was used to detect a-AB to the whole complex of antigen determinants. Using this method the elevation of a-AB against S-100 and NKP was shown at 16 cases. The disturbance of idiotype-antiidiotype regulation was revealed at this group of patients. It is suggested that insufficient level of corresponding antiidiotypes creates the conditions for autoimmune aggressor of a-AB against brain tissue.
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Morozov S.G., Asanova L.M., Gnedenko B.B., Panchenko L.F., Lavrova T.N. (1996) Voprosy meditsinskoi khimii, 42(2), 147-152.
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