Ceramides and gangliosides from bening and malignant tumors of human ovary

Andreasyan G.O., Malykh Ya.N., Dyatlovitskaya E.V.
Section: Experimental/Clinical Study
PubMed Id: 9139460
Year: 1996  Volume: 42  Issue: 3  Pages: 248-253
Composition and content of ceramides and gangliosides from different kinds of human ovary benign and malignant epithelial tumours were studied. The ceramide content was shown to decrease significantly in the tumours, especially in malignant tumours, in comparison with the normal ovary tissue. In the tumour ceramides a sphingosine base composition changes: sphinganine was found along with sphingenine, which is characteristic for normal ceramides. The fatty acid composition changes also. Main tumour gangliosides were shown to be GM3 and GD3. Their content decreases in malignant ovary tumours, especially the amount of ganglioside GD3. As a result of these changes the molar ratio Cer/Sia decreases. It can appears stimulates a tumour growth.
Download PDF:

Andreasyan G.O., Malykh Ya.N., Dyatlovitskaya E.V. (1996) Voprosy meditsinskoi khimii, 42(3), 248-253.
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)