Concentration of alpha-endorphin, beta-endorphin, gamma-endorphin and neurotensin in blood and beta-endorphin in cerebrospinal fluid of 48 patients with various forms of Huntington's disease was measured. Two modifications of immunoassay were used. The level of all neuropeptides studied was significantly decreased. Patients with a kinetiko-rigid form of the disease showed a two-fold lowering in beta-endorphin levels in cerebrospinal fluid in comparison with patients with the classic form. The relationships between these findings and clinical-biochemical characteristics of Huntington's disease are discussed.
Download PDF:
Citation:
Korshunova T.S., Nikitenko N.Yu., Ivanova-Smolenskaia I.A., Nikolskaya N.N. (1996) Endorphines and neurotensin in Huntington`s disease. Voprosy Meditsinskoi Khimii, 42(3), 263-267.
Korshunova T.S. et al. Endorphines and neurotensin in Huntington`s disease // Voprosy Meditsinskoi Khimii. - 1996. - V. 42. -N 3. - P. 263-267.
Korshunova T.S. et al., "Endorphines and neurotensin in Huntington`s disease." Voprosy Meditsinskoi Khimii 42.3 (1996): 263-267.
Korshunova, T. S., Nikitenko, N. Yu., Ivanova-Smolenskaia, I. A., Nikolskaya, N. N. (1996). Endorphines and neurotensin in Huntington`s disease. Voprosy Meditsinskoi Khimii, 42(3), 263-267.
References
Folstein S.E. Huntington's disease, a disorder of families. — J. Hopkins University Press, Baltimore, London, 1989. Scholar google search
Иванова-Смоленская И А., Верещагин Н.В., Иллариошкин С.Н. // Жур. невропатол. и псих. им. С.С.Корсакова. — 1995.-Т. 95, N 1 . - С . 52-57. Scholar google search
The Huntington's Disease Collaborative Research Group. Cell. - 1993. —V. 72. — P. 971 -983. Scholar google search
Бархатова В.П. Нейротрансмитгеры и экстрапирамидная патология. — М., —1988. Scholar google search
Kieburtt K.D., McDermott М., Marshall E. //47 Annual Meeting American Academy of Neurology. — 1995, P. 384. Scholar google search
Martin J.B. Huntington,s Disease. N. // Engl. J. Med. - 1986. - V. 13, N 315 (20). - P. 1267-1276. Scholar google search
McYeer E, Kroner В., Hoyden M. // Bopl. Psych. - 1993. - V. 33. - P. 551-553. Scholar google search
Никольская H.H. // Фенотипический полиморфизм хореи Гентингтона (клинико-генеалогические, клинико- электрофизиологические, клинико-биохимические сопоставления). — Дис. канд. мед. наук. — М., 1993. — С. 32. Scholar google search
Дмитриев А.Д., Голикова Ю.И., Кобымнский А.Г. //Нейрохимия. — 1982. — N 1. — С. 66-74. Scholar google search
Каминский Л.С. // Медицинская и демографическая статистика. — М., 1974. Scholar google search
Ашмарин И.П., Каменская М.А. // Итоги науки и техники. Серия: "Физиология человека и животных". М., ВИНИТИ. - 1986. - Т. 34. - С. 184. Scholar google search
Слепушкин ВД., Золоев Г.К., Виноградов В А., Титов М.И. // Нейропептиды. Их роль в физиологии и патологии. - Томск, — 1988. Scholar google search
Yang Н. Y., Hong J.S., Costa Е. // Neuropharmacology. - 1977. - V. 16. - P . 303-307. Scholar google search
"The endorfins", ed. by E. Costa, M. Trabucchi // New York, 1978. Scholar google search
Elliot P.J., Nemeroff C.B. in: The neurobiology of neurotensin in Neural and Endocrine Peptidesand Receptors. — PI. Press. N.Y., 1986. - P . 219. Scholar google search
Levant В., Nemeroff C.B. The psychobiology of neurotensine // "The Neuroendocrinology of Mood: Current Topics in Neuroendocrinology", edby Ganten D., Pfaff D. — Berlin, 1988. — V. 8. — P. 265. Scholar google search
Nemeroff СВ., Cain S.T. Trends Pharmacol Sci. - 1985. - V. 6, N 2. - P. 201-205. Scholar google search
Seizinger B.R., Liebiseh DC, Kish S.// J. Brain Res. - 1986. - V. 378, N 2. - P. 405-408. Scholar google search
Zech M., Bogerts B. // Acta neuropathol. - 1985. - V. 68, N 1. - P. 32-38. Scholar google search
Ferrante RJ. // Neurosci Lett. - 1986. - V. 71, N 3. - P. 283-288. Scholar google search
Коршунова Т.С., Колип ГА., Ларский Э.Г. //Журн. невроп. и психиатр, им. Корсакова. — 1984. —Т. 84, вып. 7. — С.1061-1064. Scholar google search
Jadarola M., Mouradian М. // Brain Res. - 1989. - V. 489, N 2. - P. 397-401. Scholar google search
Дубровина Н.И. // Бюлл. экспер. биол. и мед. - 1995. — Т. 119, N 2. —С. 120-124. Scholar google search
Stnible R., Powers R.E., Casanowa M.F. // J. Neuropathol and Experim. Neurol. — 1987. - V. 46, N 5. — P. 567-584. Scholar google search
Gamer D.L., Bissette G., Gao J.K. //Am. J. Psych. - 1991. - V. 148, N 4. - P. 484-488. Scholar google search
Rinne W.K., Rime J.O., Rinne J.K. // Med. Biol. - 1987. - V. 62, N 2-3. - P. 75-81. Scholar google search
Jolicer F., Rivest R., St.-Pierre et al. // Brain Res. - V. 538, N 2. - P. 187-192. Scholar google search
Jokkonen J., Hartikainen P., Soikkeli R. //Neuropeptides. - 1991. - V. 19, N 2. - P. 97-102. Scholar google search
