Mechanisms of the anticarcinogenic action of carotenoids
Vershinin A.O., Kamnev A.N. PubMed Id: 9254509
Year: 1996 Volume: 42 Issue : 4 Pages: 275-277 Carotenoids are shown to inhibit the initiation phase of carcinogenesis due to their antioxidant activity. But neither antioxidant nor pro-vitamin properties of these pigments can explain their antitumor action in many cases. Studying this problem another property of carotenoids must be accounted: their ability to modify biomembranes reinforcing lipid bilayer and decreasing its fluidity. High level of membrane fluidity is characteristic of the tumor cells and they are very sensitive to its decrease. Suppressing of membrane fluidity is the mechanism for anticancer action of tamoxifen-related compounds, and there are strong reasons to suggest the same mechanism for carotenoids.Download PDF: Keywords: carotenoids, cancerogenesis, antioxidants, membranes
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Vershinin A.O., Kamnev A.N. (1996) Mechanisms of the anticarcinogenic action of carotenoids. Voprosy Meditsinskoi Khimii, 42 (4), 275-277.
Vershinin A.O. et al. Mechanisms of the anticarcinogenic action of carotenoids // Voprosy Meditsinskoi Khimii. - 1996. - V. 42. -N 4. - P. 275-277.
Vershinin A.O. et al., "Mechanisms of the anticarcinogenic action of carotenoids." Voprosy Meditsinskoi Khimii 42.4 (1996): 275-277.
Vershinin, A. O., Kamnev, A. N. (1996). Mechanisms of the anticarcinogenic action of carotenoids. Voprosy Meditsinskoi Khimii , 42(4), 275-277.
References Show
Каротиноиды в онкологии: Материалы симпозиума / Отв. ред. И.К.Бухарова. — М., 1992. Scholar google search Bertram J.S., Pung A., Churley M. et al. //Carcinogenesis. — 1991. —Vol. 12. — P. 671-678. Scholar google search Gerster H. // Int. J. Vitamin Nutr. Res. - 1993. - Vol. 63. - P. 93-121. Scholar google search Krinsky N.I.// Amer. J. Clin. Nutr. - 1991. - Vol. 53. - P. 238-246. Scholar google search Peto R., Doll R., Buckley J.D., Spom M.B. // Nature. - 1981. - Vol. 290. - P. 201-208. Scholar google search Temple N.J., Basu Т.К. // Nutr. Res. - 1988. - Vol 8. - P. 685-701. Scholar google search Ziegler R.G.//J. Nutr. - 1989. -Vol 119. - P. 116-122. Scholar google search Zegler R.G. //Ann. N. Y. Acad. Sci. - 1993. - Vol. 691. - P. 110-119. Scholar google search Watson R.R., Rybski J. // Nutrition and Immunology / Ed. R.K. Chandra7 — New York, 1988. — P. 87-99. Scholar google search Okuzumi J., Nishino H., Murakoshi M. et at. // Ibid. - 1992. - Vol. 49. - P. 492-497. Scholar google search Philips R.W., Kikendall J.W.,Luk G.D. et al. 11 Cancer Res- 1993.-Vol.53.- P.3723-3725. Scholar google search Kummet Т., Meyskens F.L. // Seminars Oncol. - 1983. - Vol. 10. - P. 281-289. Scholar google search Bertram J.S // Pure Appl. Chem. - 1994. - Vol. 66. - P. 1025-1032. Scholar google search Matthews-Roth M.M. // Oncology. - 1982. - Vol. 39. - P. 33-37. Scholar google search Osada K., Furukawa Y, Komai M. et al. // J/ Clin. Biochem. Nutr. -1993. - Vol. 14. - P. 1-6. Scholar google search Tan B., Ow F.Z.//Amer.J.Clin. Nutr. - 1991- Vol. 53.-P. 1071-1075. Scholar google search Rettura G, Stratford F., Levenson S.M., Seifter E. //J. Nat. Cancer Inst. — 1982. — Vol. 69. — P. 73-77. Scholar google search Schwartz J.L., TanakaJ., Khandekar V. et al. // Cancer Chemother. Pharmacol. — 1992.— Vol. 29. — P. 207-213. Scholar google search Seifter E., Rettura G., Padawer J., Levenson S.M. // J. Nat. Cancer Inst. — 1982. - Vol. 68. — P. 835-840. Scholar google search Ross A.C, Ternus M.E. // J. Amer. Diet. Ass. - 1993. - Vol . 93 . - P . 1285-1290. Scholar google search Gruszecki W.I., Sielewiesiuk J. // Biochim. Biophys. Acta. — 1990. —Vol. 1023. — P. 405-412. Scholar google search Rohmer M., Bouvier P., Ourisson G. // Proc. Nat. Acad Sci. USA. -1979. - Vol. 76. - P. 847-851. Scholar google search Subczynski W.K., Markowska E., Gruszecki W.I, Sielewiesiuk J. // Biochim. Biophys. Acta. - 1992 - Vol. 1105. - P. 97- 108. Scholar google search Vandermeer B.W. //Acta Pharm Jugosl. - 1991. - Vol. 41. - P. 311-326. Scholar google search Chaturvedi V.K., Ramakrishna-Kurup C.K // Biochim. biophys. Acts. —1986. — Vol. 860. — P. 286-282. Scholar google search Chamberlain N.R., Mehrtens B.G., Xiong Z. et al. // Infect, and Immun. - 1993. - Vol. 59. - P. 4332-4337. Scholar google search Hsiao К.С., MoUer I.M. // Physiol. Plant. - 1984. - Vol. 62. - P. 167-174. Scholar google search Rottem S, Markomti. O. // J. Bact. - 1979. - Vol. 140. - P. 944-948. Scholar google search Vershinin A. // Сотр. Biochem. Physiol. — 1995. Scholar google search Yechel E, Barenholz Y. / / J biol. Chem. - 1985. - Vol. 260. - P. 9123-9131. Scholar google search Bougnoux P., Chajes V, Leroy V. et al. // Bull. Cancer. - 1990. -Vol. 77. - P. 161-164. Scholar google search Kier AB., Franklin С. // Invas. and Metastas. — 1991. — Vol. 11. - P . 25-37. Scholar google search Bums N.J., Gugger E.T., Johnston P.V., Erdman J.W. // Nutr. Res. —1991. — Vol. 11. — P. 643-648. Scholar google search Custodio J.B.A., Almeida L.M., Madeira K M // I b i d — 1993.— Vol. 1150.— P. 123-129. Scholar google search Paschenko V.Z., Vershinin А.О., Churin AA. //J. Photochem. Photobiol. B. - 1993. - V o l . 1 8 . - P . 127-130. Scholar google search Busse E., Zimmer G., Komhuber B. // Drug Res. - 1993. - Vol. 431. - P . 378-381. Scholar google search Pung A.O., Rundhaug J.E., Yoshizawa C.N., Bertram J.S. // Carcinogenesis. - 1988. - Vol. 9. - P. 1533-1539. Scholar google search