VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of transmembrane sodium gradient on myocardial creatine release

   
Alabovsky V.V., Winokurov A.A.
PubMed Id: 9254512
Year: 1996  Volume: 42  Issue: 4  Pages: 291-295
Heart maintains a gradient for creatine under physiological conditions, so that creatine release is relatively small. Calcium depletion, addition of strophanthin or decrease of sodium concentration (till 80 mM) provoke release of creatine. Elevation of transmembrane sodium gradient by raising of extracellular sodium concentration prevented loss of creatine. The effect of elevated concentration of sodium ions was blocked by strophanthin but depended on osmolarity, because solutions with the same osmolarity that hypersodium media had no protective effect on release of creatine. A sarcolemmal mechanism of Na creatine cotransports is proposed.
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Keywords: transmembrane sodium gradient, creatine, calcium, myocardium
Citation:

Alabovsky, V. V., Winokurov, A. A. (1996). Effect of transmembrane sodium gradient on myocardial creatine release. Voprosy Meditsinskoi Khimii, 42(4), 291-295.
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