Reperfusion by Ca2+-containing solution after 10 minutes of Ca2+-depletion resulted in the loss of myoglobin, depletion of ATP and phosphocreatine (calcium paradox). Exhaustion of high energy phosphates exacerbated when glucose was substituted by pyruvate or acetate. Iodoacetate (30 mcM) elevated loss of myoglobin due to calcium paradox. Addition of 120 mM glucose reduced loss of myoglobin and depletion of high energy phosphates after induction of calcium paradox. There is a close correlation between concentration of lactate and ATP in the hearts subjected to calcium paradox. Elevated activity of glycolysis protected herats against the calcium paradox.
Download PDF:
Keywords: heart, calcium paradox, energy state
Citation:
Alabovski V.V., Winokurov A.A. (1997) Dependence of sarcolemmal permeability and myocardial energy state on glycolitic activity during calcium paradox. Voprosy Meditsinskoi Khimii, 43(1), 29-33.
Alabovski V.V. et al. Dependence of sarcolemmal permeability and myocardial energy state on glycolitic activity during calcium paradox // Voprosy Meditsinskoi Khimii. - 1997. - V. 43. -N 1. - P. 29-33.
Alabovski V.V. et al., "Dependence of sarcolemmal permeability and myocardial energy state on glycolitic activity during calcium paradox." Voprosy Meditsinskoi Khimii 43.1 (1997): 29-33.
Alabovski, V. V., Winokurov, A. A. (1997). Dependence of sarcolemmal permeability and myocardial energy state on glycolitic activity during calcium paradox. Voprosy Meditsinskoi Khimii, 43(1), 29-33.
References
Hasin Y., Barry W.H. // Am. J. Physiol. - 1984. - V. 247. - P. H322-H329. Scholar google search
Paul R.J. // Am. J. Physiol. - 1983. - V. 244. - P. C399-C409. Scholar google search
Weiss J., Hilbrand B.//J. Clin. Invest. - 1985. - V. 75. - P. 436-447. Scholar google search
Chapman RA., Tunstall J. // Progr. Physiol. Mol. Biol. - 1987. - V. 50. - P. 67-96. Scholar google search
Rodrigo G.S., Chapman R.A. // J. Physopl. (G.B.) - 1991. - V. 434. - P . 627-645. Scholar google search
Eggleton P., Elsden S.R., Gough N. // Biochem. J. - 1943. - V. 37. - P . 526-529. Scholar google search
Jaworek D., Gruber W., Bergmeyer H. // Methods in enzymatic analysis. N.-Y. 1974. — V. 4. — P. 2127-2129. Scholar google search
Lamprecht W.I. // Methods in enzymatic analysis. N.-Y. Acad. Press. -1974. — P. 2101-2110. Scholar google search
