VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Identification of physico-chemical properties and immunochemical characteristic of prostate specific antigen and its complexes with protease inhibitors

   
Chekhonin V.P., Mazo E.B., Rjabukhin I.A., Grigorev M.E.
PubMed Id: 9273780
Year: 1997  Volume: 43  Issue: 3  Pages: 165-171
The study of the PSA complexes with the protease inhibitors has confirmed the opinion of possible existence the complexes of the PSA with a2-macroglobulins and a1-antihymotripsines in blood serum. The immunoenzyme analysis of the PSA and its complexes has made it possible to establish the normal level of the PSA corresponding complexes in donors blood serum. There are reasons to suppose, that the quantitative analysis of the PSA and its complexes with the protease inhibitors can be used for the early diagnosis of PC and its differential diagnosis with the prostate benign hyperplasia. In our opinion, the effect of the complex approach can be more informative than the ordinary PSA detection.
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Chekhonin V.P., Mazo E.B., Rjabukhin I.A., Grigorev M.E. (1997) Voprosy meditsinskoi khimii, 43(3), 165-171.
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