Pathways of 4-hydroxyphenylethanol formation were studied in the bovine brain. Incubation of brain homogenates with tyramine or tyrosine increased 4-hydroxyphenylethanol content only in the presence of NADH. Tyramine produced more pronounced augmentation of 4-hydroxyphenylethanol content than tyrosine. Tyrosine preparations were not contamined with tyramine. This suggests that 4-hydroxyphenylethanol may be formed from tyramine and tyrosine in NADH-dependent process. Preincubation of homogenates with 0.1 mM pargyline completely inhibited monoamine oxidases A and B and prevented NADH-dependent formation of 4-hydroxyphenylethanol from tyramine. The latter suggests that MAO is involved in formation of 4-hydroxyphenylethanol.
Panova N.G., Veselovskaya N.V., Medvedev A.E. (1997) Involvement of monoamine oxidases in formation of 4-hydroxyphenylethanol, major component of tribulin A. Voprosy Meditsinskoi Khimii, 43(3), 172-176.
Panova N.G. et al. Involvement of monoamine oxidases in formation of 4-hydroxyphenylethanol, major component of tribulin A // Voprosy Meditsinskoi Khimii. - 1997. - V. 43. -N 3. - P. 172-176.
Panova N.G. et al., "Involvement of monoamine oxidases in formation of 4-hydroxyphenylethanol, major component of tribulin A." Voprosy Meditsinskoi Khimii 43.3 (1997): 172-176.
Panova, N. G., Veselovskaya, N. V., Medvedev, A. E. (1997). Involvement of monoamine oxidases in formation of 4-hydroxyphenylethanol, major component of tribulin A. Voprosy Meditsinskoi Khimii, 43(3), 172-176.
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