VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Cytochrome P450-dependent hydroxylation and activity of glutathione-dependent liver enzymes in patients with chronic liver diseases

   
Matyushin B. N., Loginov A. S., Tkachev V. D.
PubMed Id: 9312941
Year: 1997  Volume: 43  Issue: 4  Pages: 256-260
Repression of cytochrome P450- dependent hydrohylation and demethylation in liver was demonstrated in bioptats of patients with chronic liver diseases. The inhibition of cytochrome P450 system was provoked by oxidative modification of proteins-enzymes in patients with chronic liver changes as was proposed at the same time. The activation of glutathione- dependent enzymes was revealed. So the intensification of conjugation and development processes was revealed as the compensation mechanisms of detoxication with chronic liver diseases.
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Keywords: chhronic liver disease, glutatione-dependent enzymes, cytochrome P450
Citation:

Matyushin, B. , N., Loginov, A. , S., Tkachev, V. , D. (1997). Cytochrome P450-dependent hydroxylation and activity of glutathione-dependent liver enzymes in patients with chronic liver diseases. Voprosy meditsinskoi khimii, 43(4), 256-260.
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