Age-related changes in DNA precursors metabolism in patients with mastopathology

Borzenko B.G., Pomazan B.O., Gorbachev I.A., Verkova O.A., Skorobogatova Z.M., Shvetz T.A.
PubMed Id: 9312943
Year: 1997  Volume: 43  Issue: 4  Pages: 267-271
The activity of thymidine kinase, thymidine phosphorylase, adenosine deaminase and 5,-nucleotedase of AMP was studied in tissues, blood serum and lymphocytes of 60 healthy females and 50 females with fibrocavernous mastopathy aged 23-70. It was revealed that age-related changes in the activity of thymidine kinase in blood serum reflect the analogous changes in enzyme activity in tissues of healthy women. A dirrect correlation was established between thymidine kinase activity and age both in healthy females and those with mastopathy. A significant decrease in activity of thymidine phosphorylase was demonstrated in blood serum of patients with mastopathy aged 46-60. Demermined 4-fold increase in activity of adenosine deaminase in serum was accompanied by decreased enzyme activity in lymphocytes and decreased Lymphocyte Blast Transformation Index in the same age range. The revealed metabolic changes in DNA-precursors, metabolism in patients with mastopathy aged 46-60 might be one of the reasons of increased risk of oncological deseases in this age group.
Download PDF:
Keywords: mastopathy, enzymes of thymidine metabolism, blood serum, lymphocytes

Borzenko, B. G., Pomazan, B. O., Gorbachev, I. A., Verkova, O. A., Skorobogatova, Z. M., Shvetz, T. A. (1997). Age-related changes in DNA precursors metabolism in patients with mastopathology. Voprosy meditsinskoi khimii, 43(4), 267-271.
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)