The problem of the neuro-immuno interactions on the level of the protein trans-factors, stimulating interleukin-2 (IL-2) gene expression was discussed. The physico-chemical and functional parameters of the low molecular nuclear proteins (SP and BP- 14, 18, 19 kDs) isolated from splenic and brain cells of immunized rats were studied. The binding of these proteins to the regulatory region of IL-2 gene in vitro and stimulation of the IL-2mRNA synthesis in splenic T-lymphocytes culture in normal conditions were shown. The protective effect of SP and BP on the IL-2mRNA synthesis in stressful conditions and by the T-cells treatment with the CsA was demonstrated.
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Keywords: nerwons and immune systems, gene, interleufin-2
Citation:
Korneva E.A., Golovko O.I., Kazakova T.B. (1997) Molecular-biological aspects of the interaction of the nervous and immune systems. Voprosy Meditsinskoi Khimii, 43(5), 321-329.
Korneva E.A. et al. Molecular-biological aspects of the interaction of the nervous and immune systems // Voprosy Meditsinskoi Khimii. - 1997. - V. 43. -N 5. - P. 321-329.
Korneva E.A. et al., "Molecular-biological aspects of the interaction of the nervous and immune systems." Voprosy Meditsinskoi Khimii 43.5 (1997): 321-329.
Korneva, E. A., Golovko, O. I., Kazakova, T. B. (1997). Molecular-biological aspects of the interaction of the nervous and immune systems. Voprosy Meditsinskoi Khimii, 43(5), 321-329.
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