The paper presents the results of study on polymorfisms of xenobiotic biotransformation enzymes (CYP1A1, glutathione S-transferase MI and N-acetyltransferase 2) and p53 tumor suppressor protein in patients with lung, stomach and intestine cancer. The frequency of CYP1A1-Val allele in all studied cancer groups was 3 to 5 times higher than in healthy control group. The carriers of homozygous glutathione S-transferase M1 gene deletion and slow acetylator phenotype were also of higher lung cancer risk. The substantial increase in slow acetylator phenotype frequency was shown also in the group of intestine cancer patients. The p53 Arg/Pro polymorphism study revealed the elevated frequency of Arg allele in lung and stomach cancer groups. The risk of lung cancer for the carriers of susceptible alleles depended on the age and smoking status of the patients. The results testify to a high possibility of studied polymorphic genes to be the markers of susceptibility to oncopathologies.
Lyakhovich V.V., Vavilin V.A., Gutkina N.I., Laktionova I.P., Makarova S.I., Mitrofanov D.V., Ostashevsky V.A., Chasovnikova O.B. (1997) Oncopathology: the genes and enzymes of xenobiotic-metabolizing system. Voprosy Meditsinskoi Khimii, 43(5), 330-338.
Lyakhovich V.V. et al. Oncopathology: the genes and enzymes of xenobiotic-metabolizing system // Voprosy Meditsinskoi Khimii. - 1997. - V. 43. -N 5. - P. 330-338.
Lyakhovich V.V. et al., "Oncopathology: the genes and enzymes of xenobiotic-metabolizing system." Voprosy Meditsinskoi Khimii 43.5 (1997): 330-338.
Lyakhovich, V. V., Vavilin, V. A., Gutkina, N. I., Laktionova, I. P., Makarova, S. I., Mitrofanov, D. V., Ostashevsky, V. A., Chasovnikova, O. B. (1997). Oncopathology: the genes and enzymes of xenobiotic-metabolizing system. Voprosy Meditsinskoi Khimii, 43(5), 330-338.
References
Гуляева Л.Ф., Гришанова А.Ю., Громова О.А. и др.// Микросомная монооксигеназная система живых организмов в биомониторинге окружающей среды. (Сер. Экология. Вып.32) - ГПНТБ СО РАН - Новосибирск. - 1994. - 100 С. Scholar google search
Alexandrie A.-K., Ingelman Sundberg M, Seidegard J. et al. // Carcinogenesis. - 1994. - N.9.-P. 1785-1790. Scholar google search
Anwar M., Abdel-Rahman S.Z., El-Zein R.A. et al. // Carcinogenesis. - 1996. - Vol.17. - P. 1923-1929. Scholar google search
Brockmoller J., Kerb R., Drakoulis N. et al. // Cancer Res - 1993. - Vol.53. - P.1004-1011. Scholar google search
Brockmoller J., Cascorbi I., Kerb R., et al. // Cancer Res. - 1996. - Vol.56. - P.3915-3925. Scholar google search
Broly F., Gaedigk A., Heim M. et al. //DNACell Biol. - 1991. - Vol.10. - P.545-558. Scholar google search
Drakoulis N., Cascorbi I.,Brockmoller J. et al. // Clin.Investig. - 1994. - Vol.72. - P. 240-248. Scholar google search
Harada S., Abei M., Tanaka N. et al. // Hum. Genet. - 1987. - Vol.75. - P.322-325. Scholar google search
Hayashi S., Watanabe J., Nakachi K, Kawajiri K. // J.Biochem. - 1991. - Vol.110. - P.407-411. Scholar google search
Hayashi S., Watanabe J., Kawajiri K. // Jpn. J. Cancer Res. - 1992. - Vol.83. - P.866-870. Scholar google search
Hirvonen A., Husgafvel-Pursiainen K, Anttila S. et al. // Carcinogenesis. - 1993. - Vol.14. -P.1479-1481. Scholar google search
1ARC. Cancer Causes. Occurence and Control. // Tomatis I. (Ed.) 1ARC Scientific Publications 100. - Lion. - 1990. Scholar google search
Kato S., Onda M, Matsukura N. et al. // Cancer. - 1996. - Vol.77. - P. 1654-1661. Scholar google search
Katoh Т., Nagata N, Kuroda Y. et al. // Carcinogenesis. - 1996. - Vol.17. - P. 1855-1859. Scholar google search
Kawajiri K, Nakachi K, Imai К et al. // Carcinogenesis. - 1993. - Vol.14. - P. 1085-1089. Scholar google search
Kawajiri K, Nakachi K, Imai К et al. // Crit. Rev. Oncol. Hematol. - 1993. - Vol.14. P.77-87. Scholar google search
Nakachi K, Imai K, Hayashi S. et al. // Cancer Res. - 1991 -Vol.51 - P. 5177-5180. Scholar google search
Nakachi K, Imai K, Hayashi S., Kawajiri K. // Cancer Res. - 1993. - Vol.53. - P.2994 - 2999. Scholar google search
Nazar-Stewart V., Motulsky A.G., Eaton D.L et at. // Cancer Res. - 1993. - Vol.53. - P.2313-2318. Scholar google search
Raunio H, Husgafvel-Pursianen K, Anttila S. et al.// Gene.- 1995. - V.I 59.- P.I 13-121. Scholar google search
Raunio H. Pasanen M, Maenpaa J. et al. // In: Advances in Drug Metabolism in Man. Pacifici G.M. and Fracchia G.N. (Eds) - Luxenburg. - 1995. - P.235-287. Scholar google search
Raunio H., Pelkonen O. // In: Drugs, Diet and Disease. Ioannides C. (Ed.) - Ellis Horwood Ltd, New York. - 1995. - P.229- 258. Scholar google search
Seidegard J., Vorachek W.R., Pero R. W., Pearson W.R.// Proc. Natl. Acad. Sci. USA. - 1988.-Vol.85.- P.7293-7297. Scholar google search
Zhong S., Wyllie A.H., Barnes D. et al.// Carcinogenesis. - 1993. - Vol.14.-N.9.- P.1821-1824. Scholar google search
