Oncopathology: the genes and enzymes of xenobiotic-metabolizing system

Lyakhovich V.V., Vavilin V.A., Gutkina N.I., Laktionova I.P., Makarova S.I., Mitrofanov D.V., Ostashevsky V.A., Chasovnikova O.B.
PubMed Id: 9446323
Year: 1997  Volume: 43  Issue: 5  Pages: 330-338
The paper presents the results of study on polymorfisms of xenobiotic biotransformation enzymes (CYP1A1, glutathione S-transferase MI and N-acetyltransferase 2) and p53 tumor suppressor protein in patients with lung, stomach and intestine cancer. The frequency of CYP1A1-Val allele in all studied cancer groups was 3 to 5 times higher than in healthy control group. The carriers of homozygous glutathione S-transferase M1 gene deletion and slow acetylator phenotype were also of higher lung cancer risk. The substantial increase in slow acetylator phenotype frequency was shown also in the group of intestine cancer patients. The p53 Arg/Pro polymorphism study revealed the elevated frequency of Arg allele in lung and stomach cancer groups. The risk of lung cancer for the carriers of susceptible alleles depended on the age and smoking status of the patients. The results testify to a high possibility of studied polymorphic genes to be the markers of susceptibility to oncopathologies.
Download PDF:
Keywords: oncopatholoqy, gene polymorphism, xenobiotic biotransformation enzymes, markeres

Lyakhovich, V. V., Vavilin, V. A., Gutkina, N. I., Laktionova, I. P., Makarova, S. I., Mitrofanov, D. V., Ostashevsky, V. A., Chasovnikova, O. B. (1997). Oncopathology: the genes and enzymes of xenobiotic-metabolizing system. Voprosy meditsinskoi khimii, 43(5), 330-338.
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)