The phenomenon of the dual reciprocal regulation of succinate dependent 2H+/Ca2+ exchange was studied in heart and liver mitochondria of experimental animals (allogenic heart transplantation in rat; myocardium infarction in rabbits; pulmonary arteria coarctation in dogs) and in liver bioptates from patients with stomach ulcer. Under pathology two coupled but opposite changes (simultaneous activation and inhibition) in succinate dependent Ca2+ transport occur. The inhibition of Ca2+ transport was detected by its elimination with glutamate, being mostly pronounced after cycle of ADP phosphorylation added to suspension of mitochondria. The treatment of animal with 2-oxoglutarate abolished this inhibition. This was not observed in healthy animals. The described phenomenon can prevent hyperactivation of succinate oxidation under strong pathological (distress) influences.
Saakyan I.R., Saakyan A.G. (1998) The duel reciprocal regulation of succinate oxidation in heart and liver mitochondria under pathologi. Voprosy Meditsinskoi Khimii, 44(2), 151-157.
Saakyan I.R. et al. The duel reciprocal regulation of succinate oxidation in heart and liver mitochondria under pathologi // Voprosy Meditsinskoi Khimii. - 1998. - V. 44. -N 2. - P. 151-157.
Saakyan I.R. et al., "The duel reciprocal regulation of succinate oxidation in heart and liver mitochondria under pathologi." Voprosy Meditsinskoi Khimii 44.2 (1998): 151-157.
Saakyan, I. R., Saakyan, A. G. (1998). The duel reciprocal regulation of succinate oxidation in heart and liver mitochondria under pathologi. Voprosy Meditsinskoi Khimii, 44(2), 151-157.
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