Vitamin E accumulation in dimethylnitrosamine-induced renal tumors of rats, differently supplemented with a -tocopherol

Nikiforova N.V., Yanenko E.K., Kirpatovsky V.I., Chumakov A.M., Chertkova A.I., Berman A.E., Konkova T.A.
PubMed Id: 9634718
Year: 1998  Volume: 44  Issue: 2  Pages: 158-166
The effect of a long-lasting loading with alpha-tocopherol on the development of dimethylnitrosamine-induced kidney tumors was investigated in 55 non-bred white male rats. The carcinogen was repeatedly introduced into the stomach by means of a gastric tube. Starting 24 days after the last administration of the carcinogen the alpha-tocopherol loading began and lasted up to the end of the experiment. 21 rats were loaded with vitamin E introduced into the stomach, 5 times a week at a dose of 70 mg/kg body weight. 17 rats received sunflower seed oil--the vitamin E solvent; other 17 rats received only standard ration. The control group (20 rats) were not treated with the carcinogen. One part of these rats received alpha-tocopherol by the above schedule while another part--sunflower oil alone. It was shown that the alpha-tocopherol loading had no effect on the incidence of renal tumors. Nevertheless it enhanced to some extent the rate of their development as well as the incidence of blastomes in other organs. Based on histological examination, tumors developed in kidneys were of epithelial and mesenchymal origins with the mesenchymal tumors occurring more frequently (63-69% of the total). Vitamin E content in tumor tissue of rats, loaded or not loaded with alpha-tocopherol, was much higher than that in intact kidneys of corresponding control animals, suggesting a high tumor tropism of this vitamin. Total lipid concentration of tumor tissue was 1.5 times lower than that of intact kidneys. Histological nature of tumors had no visible effect on their vitamin E and total lipid content.
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Keywords: rat kidney tumors, vitamin E, total lipids, alpha-tocopherol loading

Nikiforova, N. V., Yanenko, E. K., Kirpatovsky, V. I., Chumakov, A. M., Chertkova, A. I., Berman, A. E., Konkova, T. A. (1998). Vitamin E accumulation in dimethylnitrosamine-induced renal tumors of rats, differently supplemented with a -tocopherol. Voprosy Meditsinskoi Khimii, 44(2), 158-166.
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