The effects of single acute hypoxia (9000 m above the sea level, 3h) and intermittent hypoxia (5000 m 4 h daily during 3 and 10 days) were studied. Acute hypoxia was characterized by the increase in the content of brain serotonin, dopamine and norepinephrine accompanied by a decrease of deaminated product. The increase of monoamine contents in hypothalamus and adrenals during initial stage caused to considerable extent by their deamination and the monoamine decrease under 10-day hypoxia were typical for intermittent hypoxia. The administration of MAO a inhibitor pyrazidol promoted the increase in brain serotonin content, normalized brain catecholamine contents and demonstrated positive effect on the animal state.
Download PDF:
Keywords: hypoxia, increase of resistance, monoamine oxidase, pyrazidol, catecholamines, serotonin
Citation:
Goroshinskaya I.A., Neskubina I.V. (1998) The contents of monoamines under hypobaric hypoxia and the protective effect ofpyrazidol. Voprosy Meditsinskoi Khimii, 44(3), 248-255.
Goroshinskaya I.A. et al. The contents of monoamines under hypobaric hypoxia and the protective effect ofpyrazidol // Voprosy Meditsinskoi Khimii. - 1998. - V. 44. -N 3. - P. 248-255.
Goroshinskaya I.A. et al., "The contents of monoamines under hypobaric hypoxia and the protective effect ofpyrazidol." Voprosy Meditsinskoi Khimii 44.3 (1998): 248-255.
Goroshinskaya, I. A., Neskubina, I. V. (1998). The contents of monoamines under hypobaric hypoxia and the protective effect ofpyrazidol. Voprosy Meditsinskoi Khimii, 44(3), 248-255.
Меерсон Ф.З., Пшенникова М.Г. (1989), Стресс-лимитирующие системы организма и новые принципы профилактической кардиологии. Обзорная информация. Медицина и здравоохранение. Серия: Проблеммы кардиологии. М. №3, 72. Scholar google search
Хайсман КБ., Арефолов В.А., Маликова Л.А. (1988), Бюл. экспер. биол. и мед. 105, (3), 302-305. Scholar google search
