The literary data on development and trial of new non-viral methods of antisencenucleotide, DNA and ribozyme delivery based on the application of protein and peptideconstructions are summarised. For the creation of peptide constructions the proteins andfunctional fragments of proteins able to pass through a cellular membrane are used. Thespecial attention is paid to the transport properties of recombinant fusion proteinscontaining translocation domain.
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Keywords: gene therapy, antisense constructions, delivery of oligo - and polinucliotides into cells, protein constructions
Citation:
Pozmogova G.E., Knorre D.G. (1998) Protein and peptide constructions for DNA and oligonucleotide delivery in cell. Voprosy Meditsinskoi Khimii, 44(4), 331-337.
Pozmogova G.E. et al. Protein and peptide constructions for DNA and oligonucleotide delivery in cell // Voprosy Meditsinskoi Khimii. - 1998. - V. 44. -N 4. - P. 331-337.
Pozmogova G.E. et al., "Protein and peptide constructions for DNA and oligonucleotide delivery in cell." Voprosy Meditsinskoi Khimii 44.4 (1998): 331-337.
Pozmogova, G. E., Knorre, D. G. (1998). Protein and peptide constructions for DNA and oligonucleotide delivery in cell. Voprosy Meditsinskoi Khimii, 44(4), 331-337.
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