The essential decrease of the rate of turnover of phosphatidic acids(PA), polyglycerophosphates (PGP) and their lysoderivatives (LPGP), sphinigomyelin (SM)and lysophosphatidylcholine (LPC), phosphatidyletnanolamine (PEA) was found in male miceof balb/c strain with subacute alloxan diabetes (glucose concentration in the blood wasnot less than 14 mmol/l) during examination of phospholipid metabolism in the liver by therate of 3H-acetate and 14C-palmitate incorporation intocorresponding chromatographic phospholipid fractions. On the contrary, turnover ofphosphatidilcholine (PC) significantly increased. The of main structural phospholipidcomponents of hepatocyte cellular membranes -PEA and PC - were found to bedecreased by 41 and 32%, respectively . LPGP and PA levels decreased to a lesser extent.The level of PGP, SM, phosphatidylinositol and LPG did not differ from the control level.
Saprykina E.V., Kozlov Y. A., Sosnina N.V., Baikov A.N., Novitsky V.V. (1998) The study of phospholipid synthesis in liver of mice with alloxan diabetes . Voprosy Meditsinskoi Khimii, 44(4), 376-379.
Saprykina E.V. et al. The study of phospholipid synthesis in liver of mice with alloxan diabetes // Voprosy Meditsinskoi Khimii. - 1998. - V. 44. -N 4. - P. 376-379.
Saprykina E.V. et al., "The study of phospholipid synthesis in liver of mice with alloxan diabetes ." Voprosy Meditsinskoi Khimii 44.4 (1998): 376-379.
Saprykina, E. V., Kozlov, Y. , A., Sosnina, N. V., Baikov, A. N., Novitsky, V. V. (1998). The study of phospholipid synthesis in liver of mice with alloxan diabetes . Voprosy Meditsinskoi Khimii, 44(4), 376-379.
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