VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

The study of phospholipid synthesis in liver of mice with alloxan diabetes

   
Saprykina E.V., Kozlov Y. A., Sosnina N.V., Baikov A.N., Novitsky V.V.
PubMed Id: 9845925
Year: 1998  Volume: 44  Issue: 4  Pages: 376-379
The essential decrease of the rate of turnover of phosphatidic acids(PA), polyglycerophosphates (PGP) and their lysoderivatives (LPGP), sphinigomyelin (SM)and lysophosphatidylcholine (LPC), phosphatidyletnanolamine (PEA) was found in male miceof balb/c strain with subacute alloxan diabetes (glucose concentration in the blood wasnot less than 14 mmol/l) during examination of phospholipid metabolism in the liver by therate of 3H-acetate and 14C-palmitate incorporation intocorresponding chromatographic phospholipid fractions. On the contrary, turnover ofphosphatidilcholine (PC) significantly increased. The of main structural phospholipidcomponents of hepatocyte cellular membranes -PEA and PC - were found to bedecreased by 41 and 32%, respectively . LPGP and PA levels decreased to a lesser extent.The level of PGP, SM, phosphatidylinositol and LPG did not differ from the control level.
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Saprykina E.V., Kozlov Y. A., Sosnina N.V., Baikov A.N., Novitsky V.V. (1998) Voprosy meditsinskoi khimii, 44(4), 376-379.
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