The present paper reviews recent studies about the role of thecytochrome P-450-dependent arachidonic acid metabolites. Theremetabolites take part in the regulation of the vascular tone.They are the intracellular messenger and play an integral role inthe relation of the vascular endothelium and smooth muscle cells.The arachidonic acid metabolites regulate the activity of theionic channels. It is demonstrated that derivatives ofarachidonic acid have the role in the pathogenesis ofhypertension.
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Keywords: arachidonic acid metabolites, cytochrome P450, vascular tone
Citation:
Krzhechkovskaya V.V., Nebolsin V.E., Zheltukhina G.A., Evstigneeva R.P., Rubtsova E.R. (1998) The influence of cytochrome P450-dependent arachidonic acid metabolites in regulation of the vascular tone. Voprosy Meditsinskoi Khimii, 44(5), 417-422.
Krzhechkovskaya V.V. et al. The influence of cytochrome P450-dependent arachidonic acid metabolites in regulation of the vascular tone // Voprosy Meditsinskoi Khimii. - 1998. - V. 44. -N 5. - P. 417-422.
Krzhechkovskaya V.V. et al., "The influence of cytochrome P450-dependent arachidonic acid metabolites in regulation of the vascular tone." Voprosy Meditsinskoi Khimii 44.5 (1998): 417-422.
Krzhechkovskaya, V. V., Nebolsin, V. E., Zheltukhina, G. A., Evstigneeva, R. P., Rubtsova, E. R. (1998). The influence of cytochrome P450-dependent arachidonic acid metabolites in regulation of the vascular tone. Voprosy Meditsinskoi Khimii, 44(5), 417-422.
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