The lipid composition of high density lipoproteins was studiedin 53 patients with various forms of hereditaryhyperlipoproteinemia. 20 healthy individuals formed controlgroup. One-dimensional thin-layer chromatography on silica gelwith two solvent systems was used to separate lipid fractions ofhigh density lipoproteins. Ten fracions were identified: fourphospholipids (phosphatidylcholine, lysophosphatidylcholine,sphingomyelin, phosphatidylethanolamine) mono-, di-, andtriglycerides, free cholesterol, cholesterol esters and freefatty acids. Proportion of HDL phospholipid and cholesterolfraction got by Shimadzu (CS-930) chromato-scanner corresponds todata received with the use of traditional methods. Comparison ofhigh density lipoproteins lipid classes proportions for theindividuals with normo- and hyperlipoproteinemia demonstratesincrease of lysophosphatidylcholine and decrease ofphoshatidylethanolamine for all hereditary hyperlipoproteinemiaforms investigated in the study.
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Keywords: high density lipoprotein, hereditary hyperlipoproteinemia, cholesterol, phoshpholipids
Citation:
Tvorogova M.G., Vasin P.N., Rozhkova T.A., Kukharchuk V.V., Titov V.N. (1998) High density lipoprotein lipid composition at hereditary hyperlipoproteinemia. Voprosy Meditsinskoi Khimii, 44(5), 452-458.
Tvorogova M.G. et al. High density lipoprotein lipid composition at hereditary hyperlipoproteinemia // Voprosy Meditsinskoi Khimii. - 1998. - V. 44. -N 5. - P. 452-458.
Tvorogova M.G. et al., "High density lipoprotein lipid composition at hereditary hyperlipoproteinemia." Voprosy Meditsinskoi Khimii 44.5 (1998): 452-458.
Tvorogova, M. G., Vasin, P. N., Rozhkova, T. A., Kukharchuk, V. V., Titov, V. N. (1998). High density lipoprotein lipid composition at hereditary hyperlipoproteinemia. Voprosy Meditsinskoi Khimii, 44(5), 452-458.
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