416 workers of the enterprise of a nuclear industry aged from 52 to 78 years exposed to chronic influence of external gamma-irradiation in summary dozes 1.0-7.56 Gy and plutonium-239 incorporation, (in 32.3% of cases exceeding the allowable limit) were studied. A correlation between a complex of 26 biochemical and immunochemical parameters and the radiating factors was investigated at different haptoglobin genotypes (Hp). It was established, that the greatest number of changes of biochemical parameters related to radiating influence, was observed at the people with a genotype Hp 2-2 (7 parameters), to a lesser degree--at a genotype Hp 2-1 (5 parameters) and in some more smaller degree--at a genotype Hp 1-1 (4 parameters). All investigated people with a genotype 2-2 were characterised by increase of serum protein entropy.
Telnov V.I., Zhuntova G.V. (1998) The genotype analysis of the biochemical status at the significant dozes irradiated people. Voprosy Meditsinskoi Khimii, 44(5), 479-484.
Telnov V.I. et al. The genotype analysis of the biochemical status at the significant dozes irradiated people // Voprosy Meditsinskoi Khimii. - 1998. - V. 44. -N 5. - P. 479-484.
Telnov V.I. et al., "The genotype analysis of the biochemical status at the significant dozes irradiated people." Voprosy Meditsinskoi Khimii 44.5 (1998): 479-484.
Telnov, V. I., Zhuntova, G. V. (1998). The genotype analysis of the biochemical status at the significant dozes irradiated people. Voprosy Meditsinskoi Khimii, 44(5), 479-484.
References
Харрис Г. (1973). Основы биохимической генетики человека. М.: Мир. Scholar google search
Алтухов Ю.П. (1989) Генетические процессы в популяциях. М.: Наука. Scholar google search
Тосиюки Я., Кадзунори Ц., Сусуму С, Масатака А., Тамио Я, Масая А. (1979) Биохимия наследственности: Пер. с япон. М.: Медицина. Scholar google search
Долматова И.Ю., Рафиков Х.С. (1990) 2-ой Всес. сьезд мед. ген.: Тез. докл. М.: 133. Scholar google search
Нормы радиационной безопасности НРБ-76/87 и Основные санитарные правила работы с радиоактивными веществами и другими источниками ионизирующих излучений ОСП-72/87. М.: Энергоатомиздат, 1988. Scholar google search
Спицын В.А. (1985) Биохимический полиморфизм человека. М: Изд-во МГУ. Scholar google search