VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Structure-functional alerations in biomembranes at diabetic complications and their pharmacological corrections

   
Tatyanenko L.V., Bogdanov G.N., Varfolomeev V.N., Kotelnikova R.A., Shaposhnikova G. I., Smirnov L. D.
PubMed Id: 10599141
Year: 1998  Volume: 44  Issue: 6  Pages: 551-558
The decrease of sorbitol dehyidrogenase activity and the increase both of aldoso reductase activity and sorbitol concentration in aorta or eye lens under experimental diabetic angiopathy have been shown. The structural and functional alterations in erythrocytes membranes under angiopathy studied by spin- and luminesoense probes confirm the hypothesis on the major role of membrane pathology processes in the pathogenesis of diabetic mellitus. Pharmacological correction of diabetic angiopathy by glucophag or new antioxidant LBK-78 normalized the studied diversions on the membranes level.
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Keywords: diabetic anqiopathy, sorbitol pathway of glucose metabolism, structure and functions of biomembranes
Citation:

Tatyanenko, L. V., Bogdanov, G. N., Varfolomeev, V. N., Kotelnikova, R. A., Shaposhnikova, G. , I., Smirnov, L. , D. (1998). Structure-functional alerations in biomembranes at diabetic complications and their pharmacological corrections. Voprosy Meditsinskoi Khimii, 44(6), 551-558.
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