VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

The interstrain differences in the enzymatic activity of CYP2B1 и expression of its gene in rat liver during induction with phenobarbital and triphenyldioxane

   
Schwartz E. I., Gulyaeva L. F., Lyakhovich V.V.
PubMed Id: 10205826
Year: 1999  Volume: 45  Issue: 1  Pages: 30-36
The interstrain differences in hepatic 7-pentoxyresorufin-O-dealkylase and 16*-androstendione hydroxylase activities specific for cytochrome Р450 2В1 have been found in Sprague-Dawley, Brattleboro and Wistar rats treated with with phenobarbital, triphenyldioxane. Similar differences were found in the accumulation of corresponding mRNAs suggesting differences in expression of cytochrome P450 gene. Analysis of the enzymatic activity and mRNA level revealed positive correlation between these parameters. Thus, differences in transcriptional activity of CYP2B1 gene during induction by phenobarbital and triphenyldioxane may be one of reasons for interstrain differences between enzymatic activities of rat liver cytochrome P4502B1
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Schwartz E. I., Gulyaeva L. F., Lyakhovich V.V. (1999) Voprosy meditsinskoi khimii, 45(1), 30-36.
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