Na+,K+-ATPase activity was studied in neurones and neuroglia under conditions of convulsions caused by picrotoxin administration. Picrotoxin is a stimulant which causes convulsions by supression of presynaptic inhibition. Na+,K+-ATPase activity in neuroglia was increased in convulsion, bat was not altered in neurones. It is possible, that glial Na+, K+-ATPase activity plays the role of neuronal ion's flows regulator and neuronal protector from convulsions. In recovery period ATPase activities in neuronal and neuroglial cells run up to control
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Keywords: Na+,K+-ATPase, neurones, neuroglia, seizures, brain, the picrotoxin
Citation:
Tolstukhina T.I., Flerov M.A. (1999) Atpase activity of neurone and neuroglia under picrotoxin-induced convulsions. Voprosy Meditsinskoi Khimii, 45(2), 145-149.
Tolstukhina T.I. et al. Atpase activity of neurone and neuroglia under picrotoxin-induced convulsions // Voprosy Meditsinskoi Khimii. - 1999. - V. 45. -N 2. - P. 145-149.
Tolstukhina T.I. et al., "Atpase activity of neurone and neuroglia under picrotoxin-induced convulsions." Voprosy Meditsinskoi Khimii 45.2 (1999): 145-149.
Tolstukhina, T. I., Flerov, M. A. (1999). Atpase activity of neurone and neuroglia under picrotoxin-induced convulsions. Voprosy Meditsinskoi Khimii, 45(2), 145-149.
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