VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Pharmacokinetic sand stability of phosphodiester and phosphorothioate 3`end modified oligonucleotides inthe blood in vivo: a comparative study

   
Laktionov P.P., Bryksin A.V., Rykova E.Yu., Amirchanov N. V., Vlasov V. V.
PubMed Id: 10432555
Year: 1999  Volume: 45  Issue: 3  Pages: 206-214
In vivo stability and distribution of deoxyribooligonucleotides and 3'-end modified oligodeoxyribooligonucleotides were studied in blood serum and cells. Substitution of two 3'-end internucleotide phosphodiester bonds increased the stability of modified oligonucleotides. Modified oligonucleotides were shown to be stable in blood serum for up to 24 hours. Leukocytes did not bind oligonucleotides significantly, whereas erythrocytes accumulate mono-, di-, three-, tetranucleotides appeared in the blood stream as degradation products of the parent oligonucleotide.
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Laktionov P.P., Bryksin A.V., Rykova E.Yu., Amirchanov N. V., Vlasov V. V. (1999) Voprosy meditsinskoi khimii, 45(3), 206-214.
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