Rats genetically predisposed (PM+) and non-predisposed (PM-) to pendulum movement (spontaneous nystagm) were studied at different age. In old PM+ and PM- rats the brain MAO-A activity did not differ, unlike between young PM+ and PM- rats. In old PM+ and PM- rats, brain stem MAO-A activity was higher than in young ones. Actinomycin D lowered brain stem MAO-A activity in PM+ and PM- rats. In the absence of actinomycin D, stress elevated MAO-B activity in the brain stem of PM- rats, and a preliminary actinomycin D administration prevent the MAO-B activating effect of stress. Possible differences in MAO-A and MAO-B regulation at transcription level in PM+ and PM- are discussed
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Keywords: Monoamine oxidase, brain, spontaneous nystagm, age
Citation:
Voitenko N.N., Barykina N.N., Kolpakov V.G. (1999) Brain monoamine oxidase in ageing of rats genetically predisposed to pendulum movement. Voprosy Meditsinskoi Khimii, 45(3), 216-222.
Voitenko N.N. et al. Brain monoamine oxidase in ageing of rats genetically predisposed to pendulum movement // Voprosy Meditsinskoi Khimii. - 1999. - V. 45. -N 3. - P. 216-222.
Voitenko N.N. et al., "Brain monoamine oxidase in ageing of rats genetically predisposed to pendulum movement." Voprosy Meditsinskoi Khimii 45.3 (1999): 216-222.
Voitenko, N. N., Barykina, N. N., Kolpakov, V. G. (1999). Brain monoamine oxidase in ageing of rats genetically predisposed to pendulum movement. Voprosy Meditsinskoi Khimii, 45(3), 216-222.
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