Acute cold exposure of organism (4 hours at -20 degrees C) inhibits myocardial protein synthesis and increases cortisol/insulin index in rat blood. Preliminary repeated administration in [D-Ala2, Leu5, Arg6]-enkephalin (dalargin) prevents the decrease of myocardial protein synthesis rate after cold stress and decreases cortisol/insulin ratio. Pretreatment with naloxone at dose of 0.2 mg/kg or 2 mg/kg doesn't eliminate 'anabolic' effect of dalargin. 'Anabolic' effect of dalargin is suggested to be connected with -opioid receptor stimulation and change in insulin and cortisol secretion
Lishmanov Yu.B., Naryznaya N.V., Maslov L.N. (1999) Effect of enkephalins on the synthesis of myocardial proteins during acute cold exposure. Voprosy Meditsinskoi Khimii, 45(3), 227-231.
Lishmanov Yu.B. et al. Effect of enkephalins on the synthesis of myocardial proteins during acute cold exposure // Voprosy Meditsinskoi Khimii. - 1999. - V. 45. -N 3. - P. 227-231.
Lishmanov Yu.B. et al., "Effect of enkephalins on the synthesis of myocardial proteins during acute cold exposure." Voprosy Meditsinskoi Khimii 45.3 (1999): 227-231.
Lishmanov, Yu. B., Naryznaya, N. V., Maslov, L. N. (1999). Effect of enkephalins on the synthesis of myocardial proteins during acute cold exposure. Voprosy Meditsinskoi Khimii, 45(3), 227-231.
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