VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Variation of fructose 2.6-bisphosphate content in peripheral blood lymphocytes of patients with diabetes mellitus

   
Korovkin B.F., Belayeva N.F., Kraevoy C.A., Golubev M.A., Gorodetsky V.K., Markova M.S., Kolchenko O.L.
PubMed Id: 10432559
Year: 1999  Volume: 45  Issue: 3  Pages: 232-237
Variation of fructose 2,6-bisphosphate (F-2,6-P2) content in the peripheral blood lymphocytes of patients with diabetes mellitus (type II) was investigated. The 2.5-fold increase of F-2,6-P2 level compared with to the control group was observed in untreated patients with early stage of the disease. In patients using of peroral antidiabetic drugs that corrected diabetes F-2,6-P2 level was approached to the normal one. At the same time F-2,6-P2 content decreases in patients with severe (noncorrected) diabetes mellitus. The possible mechanisms of regulation of lymphocyte F-2,6-P2 concentration in normal conditions and diabetes mellitus are discussed.
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Korovkin B.F., Belayeva N.F., Kraevoy C.A., Golubev M.A., Gorodetsky V.K., Markova M.S., Kolchenko O.L. (1999) Voprosy meditsinskoi khimii, 45(3), 232-237.
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