VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Importance of iontransporting sarcolemmal systems in loss of amino acids duringc a depletion and myocardial damage during the calcium paradox

   
Winokurov A.A., Alabovsky V.V., Cragoe E.J.
PubMed Id: 10432560
Year: 1999  Volume: 45  Issue: 3  Pages: 238-245
The loss of myocardial aminoacids is known to depend on sodium gradientacross sarcolemma. This is regulated by changes of cellular volume as well. It issuggested that loss of aminoacids can be regulated by blocking of anion - transpotingsystems during Ca-free perfusion. It have been found that calcium depletion fromextracellular medium exacerbates release ofaminoacids two- four fold. Sodium lowering(from 140 mM to 30 mM) accelerates and sodium elevation (from 140 mM to 200 mM) attenuatesloss oftaurine, glutamine, glycine, glutamate, aspartate, alanine and asparagine, but doesnot hydrophobic aminoacids.
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Keywords: heart, "calcium paradox", Na+, damage, creatine, amino acids
Citation:

Winokurov, A. A., Alabovsky, V. V., Cragoe, E. J. (1999). Importance of iontransporting sarcolemmal systems in loss of amino acids duringc a depletion and myocardial damage during the calcium paradox. Voprosy meditsinskoi khimii, 45(3), 238-245.
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