Aminopeptidase activity in lymphoid cells of patients with various lymphoproliferative diseases was studied. The enzyme activity was detected in lysates of all leukemic B- and T-cells. The lymphoid cells contained aminopeptidases of at least two classes: metallo- and SH-dependent enzymes. The SH-dependent aminopeptidase with pH optimum 8.5-9.0 was revealed in lymphoid cells for the first time, and it seems to belong to a poorly studied aminopeptidase family.
Rieman D., Kehlen .A., and Langner J. (1999) Review Immunology Today, 20, 83-88. Scholar google search
Kenny A.J., Stephenson S.L., Turner A.J. (1987) in Mammalian ectoenzymes. (Kenny A. J., Turner A. J. ,eds.), Elsevier, Amsterdam., pp.169-207. Scholar google search
Favaloro B.J., Browning Т., Nandurkar H., Sartor M., Bradstock K.F., Routs J. (1995) Leukemia Res., 19, 659-666. Scholar google search
Saito M., Kumagai M., Okazaki Т., Nakazava S., Shapiro L.H., Look А. Т., Campana D. (1995) Leukemia, 9, 1508-1516. Scholar google search
Murray H., Turner A. J., Mcclaren H., Kenny A.J. (1995) Leukemia & Lymphoma, 17, 501-595. Scholar google search
Wex T, Lendeckel U., Kahne Т., Ittenson A., Frank K, Ansorge S. (1997) Biochem. & Biophys. Acta, 1355, 147-154. Scholar google search