VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Changes in the activity of neutral and acidic isoformes of sphingomyelinase in hepatoma-22, regenerating and ischemic liver

   
Alessenko A.V., Zubova E.S., Dudnik L.B., Galperin E.I., Platonova L.V., Shono N.I., Chevokin A.Yu., Dyatlovitskaya E.V.
Section: Experimental Study
PubMed Id: 10761212
Year: 1999  Volume: 45  Issue: 6  Pages: 472-481
Activity of neutral and acidic sphingomyelinases (N- and A-SMases) were studied in regenerating liver after partial hepatectomy (during 48 hrs after operation), in ischemic liver during 15, 30 min and 1 and 2 hrs ischemia and during following reperfusion (from 5 min up to 2 hrs), in hepatoma- 22 after 15 days of transplantation and in liver of tumor bearing animals. It was shown that activity of N-SMase is increased in hepatoma-22 and in regenerating liver and it is decreased in ischemic liver. Following reperfusion of ischemic liver area activity of enzyme was found to have returned to baseline in dependence on time of ischemia and reperfusion. Activity of A-SMase is decreased in tumor, is not changed in regenerating liver and increased after long time of ischemia. It was supposed that N-SMase is involved in cell proliferation, but A-SMase is connected with cell damage.
Download PDF:
Reference:

Alessenko A.V., Zubova E.S., Dudnik L.B., Galperin E.I., Platonova L.V., Shono N.I., Chevokin A.Yu., Dyatlovitskaya E.V. (1999) Voprosy meditsinskoi khimii, 45(6), 472-481.
References  
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)