The influence of 400 mM ethanol on the activity of monoamine oxidase type B (MAO-B) of blood platelets has been studied in vitro in 30 alcoholic patients and 30 healthy volunteers. Benzylamine was used as a substrate for MAO-B. MAO-B inhibition by ethanol was higher in alcoholics compared to healthy volunteers. The higher vulnerability of MAO-B of alcoholics inhibiting action to of ethanol may be one of the mechanisms underlying some symptoms of alcoholism.
Krupitsky E.M. et al. Ethanol inhibits monoamine oxidase b activity in blood platelets of alcoholic patients // Voprosy Meditsinskoi Khimii. - 1999. - V. 45. -N 6. - P. 489-493.
Krupitsky E.M. et al., "Ethanol inhibits monoamine oxidase b activity in blood platelets of alcoholic patients." Voprosy Meditsinskoi Khimii 45.6 (1999): 489-493.
Krupitsky, E. M., Karandashova, G. F., Vostrikov, V. V., Lavrova, N. M., Grinenko, N. I., Slavina, T. Y., Grinenko, A. Y. (1999). Ethanol inhibits monoamine oxidase b activity in blood platelets of alcoholic patients. Voprosy Meditsinskoi Khimii, 45(6), 489-493.
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