VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Protection of miceby cholinesterase inhibitors of the class of carbamates against poisoning by armine andits dependence on certain physico-chemical indicators

   
Prozorovsky V.B., Pavlova L.V., Suslova I.M., Sazonova A.V., Kokushkina A.V.
PubMed Id: 10761219
Year: 1999  Volume: 45  Issue: 6  Pages: 525-528
A series of aminostigmin derivatives with various substituents at nitrogen in the second position of the pyridine ring, has been tested. The efficacy of preventing the death of mice poisoned by armine in five of the seven substances correlates with the constant of the rate of carbamylation of acetylcholinesterase in the in vitro experiments and with the hydrophobic nature. It is suggested that the phenomenon of protection of animals against the toxic effect of organophosphorous compounds involves the "leaving portion" of the molecule of carbamates.
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Prozorovsky, V. B., Pavlova, L. V., Suslova, I. M., Sazonova, A. V., Kokushkina, A. V. (1999). Protection of miceby cholinesterase inhibitors of the class of carbamates against poisoning by armine andits dependence on certain physico-chemical indicators. Voprosy Meditsinskoi Khimii, 45(6), 525-528.
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