The main events caused by anaphilaxis in selenium haemostasis in rats include significant increase of selenium excretion with urine (6,36± 1,18 nM Se/18 h., n=10, compared with 1,72± 0,38 nM Se/18 h., n=10) and decrease of selenium plasma/selenium erythrocytes ratio from 0,939 to 0,791. Reduced glutathione (G-SH) administration led to 1,5-fold decrease of plasma selenium level and 1,3-fold increase of selenium concentration in intestinal walls of sensitised rats (r=-0,720, P<0,001). Chromatographic separation of plasma proteins showed that intragastric intubation of G-SH to sensibilised rats significantly decreased the protein P content and did not influence the concentration of Se-GSHPx, thus indicating the local selenium acceptor role of G-SH. G-SH administration did not influence the intestinal permeability in sensitised rats while use of complex additive: G-SH and selenium enriched spirulina – normalised the latter parameter and the ratio of protein P/Se-GSHPx in plasma.
Golybkina N.A., Mazo V.K., Gmoshinski I.V., Zorin S.N., Tambiev A.H., Kirikova N.N. (2000) The selenium haemostasis in rats during anaphylaxis event: effect of reduced glutathione and selenium enriched spirulina. Voprosy Meditsinskoi Khimii, 46(1), 22-27.
Golybkina N.A. et al. The selenium haemostasis in rats during anaphylaxis event: effect of reduced glutathione and selenium enriched spirulina // Voprosy Meditsinskoi Khimii. - 2000. - V. 46. -N 1. - P. 22-27.
Golybkina N.A. et al., "The selenium haemostasis in rats during anaphylaxis event: effect of reduced glutathione and selenium enriched spirulina." Voprosy Meditsinskoi Khimii 46.1 (2000): 22-27.
Golybkina, N. A., Mazo, V. K., Gmoshinski, I. V., Zorin, S. N., Tambiev, A. H., Kirikova, N. N. (2000). The selenium haemostasis in rats during anaphylaxis event: effect of reduced glutathione and selenium enriched spirulina. Voprosy Meditsinskoi Khimii, 46(1), 22-27.
