The influence of co-administration of alpha-methyl-p-tyrosine (inhibitor of catecholamine synthesis) and alpha-(+) beta-adrenergic antagonists under conditions of acute hypobaric hypoxia or pretreatment with epithalamin on cyclic nucleotide content in the pineal gland of juvenile male albino rats was investigated. Acute hypoxia was accompanied by increase of pineal level of cyclic nucleotides and administration of adrenoreceptor antagonists attenuated this effect. Pretreatment of animals with adrenoreceptor antagonists did not influence the effect of acute hypobaric hypoxia on pineal cyclic nucleotide content. This suggests involvement of non-adrenergic mechanisms into augmentation of pineal cyclic nucleotide level. Administration of epithalamin caused an increase of pineal cGMP. Administration of epithalamin to rats pretreated with adrenoreceptor antagonists increased pineal cGMP and to a lesser extent cAMP content. The latter suggests that epithalamin effect was not mediated via sympathetic innervation. It is concluded that non-adrenergic innervation and humoral regulatory mechanisms are obviously involved into activation of pineal gland under conditions of acute stress.
Zamorsky I. I., Pishak V. P. (2000) Role of non-adrenergic regulation in the reaction of pineal gland on acute hypoxia and epithalamin administration to rat. Voprosy Meditsinskoi Khimii, 46(1), 28-35.
Zamorsky I. I. et al. Role of non-adrenergic regulation in the reaction of pineal gland on acute hypoxia and epithalamin administration to rat // Voprosy Meditsinskoi Khimii. - 2000. - V. 46. -N 1. - P. 28-35.
Zamorsky I. I. et al., "Role of non-adrenergic regulation in the reaction of pineal gland on acute hypoxia and epithalamin administration to rat." Voprosy Meditsinskoi Khimii 46.1 (2000): 28-35.
Zamorsky, I. , I., Pishak, V. , P. (2000). Role of non-adrenergic regulation in the reaction of pineal gland on acute hypoxia and epithalamin administration to rat. Voprosy Meditsinskoi Khimii, 46(1), 28-35.
References
Аниашов В. Н., Рейтер Р.Д. (1990) Вопр. онкологии. 36, 259-268. Scholar google search
Анисимов В.Н. (1997) Рос. физиол. журн. им. И. М Сеченова. 83 (8), 1-13. Scholar google search
Collin J.-P., Fame J.-P., Falcon J., Voisin P., Brisson P., Mirshahi M. (1988) M/S: Med Sci., 4, 16-26. Scholar google search
Tomalik Т., Peschke D., Peschke E. (1988) Gegenbaurs morphol. Jahrb., 134, 131-141. Scholar google search
Lynch H. J., Deng M.-H. (1986) J. Neural Transm. Suppl. 21, 461-473. Scholar google search
Березовский В. А., Бойко К. А., Клименко К. С, Левченко М. Н„ Назаренко А. И., Шумщкая Н. М. (1978) Гипоксия и индивидуальные особенности реактивности /Под общ. ред. В. А. Березовского. -Киев: Наук, думка. 216. Scholar google search
Резников А. Г., Носенко Н. Д., Демкив Л. П. (1978) Пробл. эндокринол., 24 (2), 48-53. Scholar google search
Арушанян Э. Б., Бинатова К Ю., Попов А. В., Попова А. П. (1991) Фармакол. и токсикол., 54 (4), 8-11. Scholar google search
Аникин Г.Д., Воробьева Н.Д. (1997) Фармакол. вод.-солев. обмена и почек: 5 Всерос. науч. конф. -Чебоксары. 4-5. Scholar google search
Zimmermann R.С, Krahn L, Klee G. (1994) Clin. Endocrinol. 79, 1110-1114. Scholar google search
Бондаренко Л.А., Анисимов В.И. (1992) Бюл. экспер. биологии и медицины, 113, 194-195. Scholar google search
Васильев Г.А., Медведев Ю.А., Хмельницкий О.К. (1974) Эндокринная система при кислородном голодании. - Л.: Наука. 7-16. Scholar google search
