VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Melatonin influence on wound-healing and some biochemical characteristics of granulation tissue of rats

   
Kim Ren Hva1, Olshevskii E.G.1, Markina L.G.1, Abramov Yu.V.1, Volodina T.V.1, Kozeltzev V.L.1, Bykov V.A.1

1. Research Centre for Biomedical Technology, Moscow
PubMed Id: 10802887
Year: 2000  Volume: 46  Issue: 1  Pages: 52-61
The influence of melatonin application on wounds healing and biochеmical composition of rat regenerating granulation tissue was studied. Melatonin decreased healing rate of wounds. The differences in electrophoretic pattern of proteins extracted by neutral saline solutions were detected. Melatonin increased quantity of neutral soluble collagen fraction and gene expression of minor types of collagen in normal skin. spectrum of glycosaminoglycans’ was changed, and earlier increase of chondroitinsulfats induced by administration of melatonin was observed
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Kim Ren Hva, Olshevskii E.G., Markina L.G., Abramov Yu.V., Volodina T.V., Kozeltzev V.L., Bykov V.A. (2000) Voprosy meditsinskoi khimii, 46(1), 52-61.
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